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What are N.O. boosters?
N.O. boosters are dietary supplements that are supposed to contribute to a better supply of nitric oxide to the body. This in turn should lead to a widening of the blood vessels and thus to an improved blood flow.
N.O. boosters are popular with athletes. They hope for more "pump" from it. This is the term used to describe the feeling that many athletes have during muscle training, which is usually perceived as very pleasant and thus increases motivation, when the muscles expand significantly due to the inflowing of blood.
What is N.O.?
The abbreviation N.O. stands for nitrogen monoxide: A colourless and odourless poisonous gas.
The pharmacologist Ferid Murad discovered in the late 1970s that organic nitrates release N.O., which causes the blood vessels to expand.
Ferid Murad, Robert Furchgott and Louis Ignarro received the 1998 Nobel Prize in Physiology and Medicine. They succeeded in proving the role of N.O. as a messenger substance in the organism and the importance of N.O. for the blood supply for the first time. 
What does N.O. do?
“Nitric oxide (N.O.) is a poison gas - and at the same time indispensable for life. It regulates blood pressure, helps with learning and erects the penis." (Wissenschaft.de) 
The residents of the Tibetan highlands have around ten times more N.O. in their blood than the residents of the lowlands: This doubles the blood flow and enables an adequate supply of oxygen. So they are well adapted to life at around 4000 meters. 
N.O. is also important for the normal function of the intestines, lungs, kidneys, liver and pancreas as well as for supporting diarrhoea illnesses.