Vitamin B12 Synergy

Vitamin B12 Synergy lozenges combine 3 natural forms of vitamin B12 into one highly effective formula. These are bioactive methylcobalamin and adenosylcobalamin, as well as hydroxocobalamin, a vitamin B12 form with depot-storage characteristics, for a long-lasting effect.

All of these 3 forms of vitamin B12 naturally occur in our diet, performing various functions in the body.

The sublingual absorption via the oral mucosa and the broad-spectrum efficacy of these three forms of vitamin B12, ensure optimal vitamin B12 supply. Vitamin B12 Synergy is ideal for those who suffer from digestive disorders in the gastrointestinal tract, yet strive to achieve the most effective vitamin B12 supply possible.

Advantages of Vitamin B12 Synergy:

• contains the 3 natural forms of vitamin B12
• provides a total of 1200 mcg of vitamin B12 per tablet
• sublingual absorption is ideal for those with gastrointestinal problems
• gentle on the teeth, as it is sweetened with xylitol
• free of any flavors
• suitable for vegans and vegetarians

What forms of Vitamin B12 does Vitamin B12 Synergy contain?

Vitamin B12 Synergy contains the two bioactive forms of vitamin B12: methylcobalamin and adenosylcobalamin, which are active in the body, without having to be converted.

In addition, it delivers hydroxocobalamin, which binds itself to transport molecules in the body, and thereby becomes a depot-storage form of B12. If required, it can be converted into the two active forms of B12, methylcobalamin or adenosylcobalamin.

1. Methylcobalamin - this naturally active co-enzyme form of vitamin B12 is active, especially in the cytoplasm, in the brain and in the nervous system. There it is responsible for the protection and regeneration of the nerves, the formation of neurotransmitters and the production of the genetic materials DNA and RNA.

Methylcobalamin is also responsible for the reactivation of folic acid, which is why a B12 deficiency can lead to folic acid deficiency. Methylcobalamin is also needed to convert homocysteine to methionine.

Methionine is a precursor of S-adenosylmethionine (also called SAM or SAMe), which releases its methyl group to a variety of enzymes. These, in turn, are involved in detoxification, regulation of the enzymes and the biosynthesis of various neurotransmitters. A lack of SAMe can lead to depression, mood swings and various other psychological symptoms.

Due to its far-reaching effects on folic acid and SAMe, methylcobalamin plays an important role in the normal functioning of the nervous system and proper cell division.

2. Adenosylcobalamin - this second natural bioactive form of B12 can also be directly utilized by the body. This form of vitamin B12 is the most abundant one in our nutritional intake, and it is also the one most present in all tissues and organs (especially in the liver).

Adenosylcobalamin acts directly in the mitochondria, where its effect in the citrate cycle is crucial, for the formation of cell energy.

It activates the enzyme methylmalonyl-CoA mutase, which is important for the production of fatty acids and the formation of the DNA building blocks. A lack of adenosylcobalamin can lead to neurological and cognitive disorders, underweight, chronic fatigue and muscle weakness.

3. Hydroxocobalamin - is the most common form of vitamin B12 in our diet and blood. Hydroxocobalamin is bound to the body's own transport molecules, having an excellent depot-storage function. This natural precursor is converted either into the bioactive methylcobalamin or adenosylcobalamin, as necessary, ensuring a consistent, long-lasting supply of vitamin B12.

Vitamin B12 Synergy does not contain cyanocobalamin. It is an inactive form of B12, which has to be converted in the body in several stages, into another form of vitamin B12. Since it has poorer bio-availability and cannot be activated in certain people with metabolic disorders, cyanocobalamin is not recommended by experts.

What can vitamin B12 do for our health?

• contributes to normal energy metabolism
• supports the normal functioning of the nervous system
• contributes to normal psychological function
• supports normal homocysteine metabolism
• important for the formation of red blood cells
• supports the normal function of the immune system
• helps reduce tiredness and fatigue
• has a function in cell division

A Vitamin B12 deficiency is widespread

Vitamin B12 is one of the water-soluble vitamins and is very safe. It is only present in food of animal origin. Vegans and vegetarians are therefore particularly at risk of suffering from a deficiency. This also applies to older people, as the ability to absorb and utilize vitamin B12 from food decreases sharply with age.

If you know, or suspect, that you may suffer from a vitamin B12 deficiency, you are not alone. Recent studies have shown that one in four adults suffer from a deficiency of this vital vitamin. Nearly half of the population has suboptimal blood levels.

Inadequate intake of vitamin B12 through the diet leads to vitamin B12 deficiency, which can have serious health consequences. Nutritional supplements are effective, and in many cases necessary, to correct a vitamin B12 deficiency.

Possible consequences of a vitamin B12 deficiency:

• Irritability, mood swings, feelings of fear, aggressiveness
• Memory loss or dementia
• Neuralgia
• Tingling in the hands and feet
• Weakness, fatigue, dizziness
• Increased susceptibility to infections, paleness of the face, white lips
• Restricted sense of smell and touch
• Shortness of breath (due to lack of red blood cells)
• increased homocysteine level
• low hemoglobin

Vitamin B12 should always be supplemented with biotin and folic acid

Those who take vitamin B12 as a dietary supplement should also take a daily dose of 2,5 to 5 mg biotin and 400 to 800 mcg folic acid. Because the supply of vitamin B12 increases the body's need for biotin, sit can lead to skin problems such as pimples, brittle nails and hair loss.