BioActive Folate - the most bioactive form of folic acid
Folate and folic acid are also known as vitamin B9 and are one of the essential B vitamins. Actually, folic acid is only found in our diet in the form of folate. It is mainly found in green leafy vegetables, sprouts, fruits, nuts, dairy products, egg yolks and liver.
However, folates are not very stable, and about 60-90% of folate is destroyed during cooking and through exposure to light. As a result, even nutrition-conscious people often find it difficult to meet their folate need through diet alone.
On top of that, only about 50% of the folate that actually makes its way into the body is absorbed. The reason for this is that enzymatic processes in the small intestine must first reduce folate to 5-methyltetrahydrofolate (5-MTHF). Only in this form it can be transported in the blood and perform its tasks in tandem with other vitamins such as B12 and B6.
Folic acid is primarily offered as a nutritional supplement, since to date it has not been possible to stabilize folate. But even folic acid must first be converted in the body into the active form of folate-5-MTHF so that it can be used by our cells.
BioActive Folate containing Quatrefolic - the active, bioavailable form of folic acid
BioActive Folate contains patented Quatrefolic, the bioactive, stable form of folate in the form of 5-methyltetrahydrofolate (5-MTHF). This form of folate is immediately available in the body. It is more effective than conventional folic acid because it can perform its tasks directly without having to be first converted into active folate.
Why BioActive Folate capsules are the best folic acid capsules you can buy:
- high dose of 800mcg per capsule Quatrefolic
- this corresponds to 400mcg highly bioavailable folate per capsule
- provides 5-Methyl-Tetrahydrofolate (5-MTHF), the most bioactive form of folic acid
- has a higher bioavailability than conventional folic acid
- is also effective if the enzyme defect (MTHFR mutation) is present
- increases folate levels faster than conventional folate
- is free of allergens, such as gluten, lactose or soy
- is guaranteed free of any additives
- filled into small, easy to swallow capsules
- suitable for vegetarians, vegans and diabetics
- has a very good price/performance ratio
Quatrefolic - the most effective and stable form of folic acid
After years of research, an Italian manufacturer has successfully stabilized the bioactive folate form 5-MTHF. This was achieved by binding the folate to vegetal glucosamine. The result is Quatrefolic, which is currently the most effective, stable form of folate with the highest bioavailability.
Quatrefolic passes through the small intestine into the bloodstream and is subsequently absorbed directly into the body's cells, without having to be first converted in the body, as is the case with normal folic acid or folate obtained from food. This permits the folate in the form of 5-MTHF absorbed with Quatrefolic to directly carry out its key tasks in the body's metabolism.
Quatrefolic is also the only form of folate that can cross the blood-brain barrier. This is crucial, as scientists believe a deficiency of folic acid in the brain to be a risk factor for the development of depression, Alzheimer's disease or other neurological diseases.
Since Quatrefolic can be directly absorbed by the body without loss, half of the amount usually recommended in the form of folic acid is sufficient.
Quatrefolic acts directly and independently of enzymes
As previously mentioned, folic acid or folate obtained from food must first be converted by the body into the active folate form 5-MTHF. However, roughly half of all individuals have reduced enzyme function due to a genetic defect, the so-called MTHFR mutation, which can be detected through a gene test.
If the necessary enzymes are missing, unmetabolized conventional folic acid cannot be converted into the active folate 5-MTHF. Since 5-MTHF also activates the inactive form of vitamin B12 - Cobalamin - the presence of this genetic defect also impairs all vitamin B12 metabolism.
This explains why, despite adequate intake of folic acid, some individuals' folate blood levels are too low and they also show symptoms of vitamin B12 deficiency. Therefore, these individuals definitely require the active form of folic acid contained in BioActive Folate capsules, as well as active vitamin B12 in the form of methylcobalamin.
The absorption of food-derived folate and folic acid can also be diminished by absorption deficiencies in the intestine caused by e.g. celiac disease, medications or contraceptives.
Why do we need folic acid?
A sufficient supply of folates is very important since they are involved in numerous metabolic processes in the body and thus play a vital role in health.
Folic acid is important for
- healthy cell division and cellular function
- the breakdown of homocysteine, which can damage blood vessels
- the formation of blood cells, thanks to its role in vitamin B12 metabolism
- healthy formation of mucosa
- proper brain function
- the protein and fat metabolism
Folic acid deficiency is one of the most underestimated health problems in Europe, and many people absorb far too little of this important vitamin through food.
Folic acid deficiency can lead to numerous symptoms:
- Neural tube defects in unborn children
- increased risk of abortion
- elevated homocysteine levels in the blood
- increased risk of heart and circulatory diseases
- anemia caused by insufficient vitamin B12 activation
- brain dysfunction (e.g. depression, forgetfulness, dementia and Alzheimer's)
- predisposition to thrombosis and embolism
- increased risk of gastrointestinal problems
- premature skin ageing
- mucosal changes
- wound healing disorders
- immune deficiency and allergies
- increased risk of cell degeneration
Folic acid and vitamin B12 work closely together
Folic acid and vitamin B12 are directly dependent on each other for their metabolism. Among others, the active folate form 5-methyltetrahydrofolate (5-MTHF) activates cobalamin, the reduced vitamin B12 form, transforming it into methylcobalamin. Vitamin B12 can only perform its tasks in the body in this activated form.
Methylcobalamin delivers its methyl group to homocysteine, turning it into methionine. This, in turn, is converted into S-adenosylmethionine (SAM), which has a significant influence on the genes, hormones, the production of antioxidants, neurotransmitters, and detoxification.
On the other hand, vitamin B12 is responsible for reactivating folic acid by converting it back into the form of tetrahydrofolate, which is usable by the body. Consequently, vitamin B12 deficiency can indirectly lead to folic acid deficiency since it remains stuck in an inactive form after some time.