Folic acid in a high dose – with Quatrefolic® for maximum bioavailability and bioactivity

Typically, healthy people can get adequate amounts of folate – also known as folic acid or vitamin B9 – by eating a balanced diet. However, achieving this may not always be feasible - either temporarily or permanently.  

Folates are not very stable and around 60 to 90% of the folate in food is destroyed during cooking or by exposure to light. In addition, stress and certain illnesses, for example, can result in higher folic acid requirements. Even nutrition-conscious people often find it difficult to cover their folate and folic acid requirements with food.  

Pregnant women, women looking to conceive and women who are not using contraception are expressly recommended to take folic acid supplements to ensure an adequate supply in pregnancy – be it planned or unplanned. [1] 

It can therefore be sensible to ensure optimal folate or folic acid intake by taking appropriate dietary supplements. 

Vitality Nutritionals BioActive Folate 800 µg capsules  

BioActive Folate 800 µg capsules are a high-dose, pure folate nutritional supplement. The capsules contain the patented premium branded ingredient Quatrefolic®, a bioactive, stable form of folate in the form of 5-methyltetrahydrofolate (5-MTHF).  

A single Vitality Nutritionals BioActive Folate 800 µg capsule contains 

• 1800 µg Quatrefolic® 

• of which 800 µg active folate 

High bioavailability and bioactivity due to Quatrefolic® 

"Folate is the natural form of the vitamin that can be found in the body and in food and is composed of various physiological compounds. The industrially manufactured form is called folic acid and is used to fortify foods and vitamin supplements." (dge.de) [2] 

Both folates and folic acid must first be converted into the active folate form 5-MTHF in the body in order to be used by the body's cells. 

As a stable 5-methyltetrahydrofolate (5-MTHF), Quatrefolic® is both highly bioavailable and bioactive: It can be directly absorbed and used by the body without first having to be converted into active folate in the body. 

Result of extensive research 

To make 5-MTHF, the bioactive form of folate, directly available to the body through a dietary supplement, it must be stabilized. After years of research, an Italian manufacturer succeeded in doing this by binding the folate to plant-based glucosamine. The result? Quatrefolic®, currently the most effective stable form of folate with maximum bioavailability. 

Quatrefolic® enters the bloodstream via the small intestine and is then absorbed directly into the cells without first having to be converted in the body, as is the case with typical folic acid or folate from food. The folate absorbed via Quatrefolic® in the form of 5-MTHF can thus immediately fulfill its important metabolic tasks. 

Quatrefolic® is also the only form of folic acid that can cross the blood-brain barrier and also have an effect in the brain. Scientists assume that a folic acid deficiency in the brain is a risk factor for developing mood swings or forgetfulness. 

Wide range of benefits of folate/folic acid  

The following information has been scientifically studied and confirmed by the European Food Safety Authority (EFSA). [3] 

Folate / folic acid for reproduction 

• Folate contributes to the growth of placenta during pregnancy 

Folate / folic acid for the cells 

• Folate plays a role in cell division 

Folate / folic acid for the brain, nervous system and mental balance 

• Folate contributes to normal mental function 

Folate / folic acid for the heart, circulation and blood vessels 

• Folate contributes to normal formation of blood cells 

Folate / folic acid for the immune system 

• Folate contributes to normal functioning of the immune system 

Folate / folic acid for performance

• Folate contributes to the reduction of fatigue and tiredness 

Folate / folic acid for the metabolism 

• Folate contributes to normal synthesis of amino acid 

• Folate contributes to normal homocysteine metabolism 

Overview of the advantages of BioActive Folate 800 µg 

• with a high dose of folate – 800 µg 

• pure folate without undesirable additives  

• for targeted, pure folate/folic acid supplementation 

• ideal for increased or high requirements 

• patented branded ingredient Quatrefolic® for maximum bioavailability and bioactivity 

• Quatrefolic® enters the bloodstream via the small intestine and is absorbed directly into the cells without first having to be converted in the body 

• Quatrefolic® is the only form of folic acid that can cross the blood-brain barrier 

• highest possible quality and purity 

• guaranteed free from GMOs 

• vegan, lactose-free, gluten-free 

For whom are BioActive Folate 800 µg capsules ideal? 

"Food supplements are effective when the right nutrients are consumed by appropriate individuals at the right time and in the correct amounts." (verbraucherzentrale.de) [4] 

Vitality Nutritionals BioActive Folate 800 µg capsules are ideal for providing overall support for maintaining the folate balance, especially for those with an increased need for folate:  

• The German Nutrition Society (Deutsche Gesellschaft für Ernährung, DGE) advises women who are trying to or could conceive to eat a diet rich in folate. In addition, it is recommended to take 400 µg of folic acid or equivalent doses of other folates daily in the form of a supplement to prevent neural tube defects. This additional intake of a folic acid or folate supplement should begin at least 4 weeks before the start of pregnancy and be maintained during the first trimester. [2] In other countries, e.g. the USA, the recommended daily doses are 600 µg [5] or 800 m µg [6].Ask a specialist, e.g. your doctor, whether your diet is rich in folate and whether you require a folate or folic acid supplement in a higher dosage.  

• People with a permanently or temporarily restricted folate supply who do not get sufficient quantities of folate from their diet, e.g. due to their diet or while trying to lose weight. 

• People with an increased need for folate, e.g. due to illness, medication, stress, psychological strain or high alcohol consumption.  

• Elderly people with limited folate absorption due to age-related changes in digestive function. 

• etc. 

For whom are folate or folic acid in high doses not suitable?  

Folic acid supplements in high doses are not suitable for 

• those with folic acid hypersensitivity 

• those taking certain medications, e.g. certain anti-infectives, antibiotics such as chloramphenicol, contraceptives, some cancer drugs; if in doubt, seek medical advice 

• children, adolescents and adults who would exceed the respective tolerable total intakes with the supplement, see also the section "Do folate or folic acid in high doses have side effects?" 

Do folate or folic acid in high doses have side effects?

According to the latest findings, a high intake of folates, which naturally occur in food, is not harmful. In contrast, a high intake of folic acid, e.g. via food supplements or fortified foods, can be harmful if the recommended intake is exceeded.  

According to the European Food Safety Authority (EFSA), the tolerable upper intake level for adults is 1000 µg of folic acid per day. For children and adolescents aged 1 to 17 years, the tolerable upper intake level is 200 to 800 µg per day. If the folic acid intake is higher over a longer period of time, the risk of adverse effects is increased. [2]